| 產(chǎn)品編號 | bsm-30220M-PE |
| 英文名稱 | human CD284 (TLR4)/PE |
| 中文名稱 | PE標(biāo)記人CD284 (TLR4)單克隆抗體 |
| 別 名 | TLR-4; TLR 4; ARMD10; CD 284; CD284; CD284 antigen; Homolog of Drosophila toll; hTol; Toll (Drosophila) homolog; TOLL; Toll Endotoxin Hyporesponsiveness; Toll like receptor 4; Toll like receptor 4 precursor; TLR4_HUMAN. |
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Specific References (1) | bsm-30220M-PE has been referenced in 1 publications.
[IF=6.429] Ying Jun. et al. Aspirin increases chemosensitivity of colorectal cancer cells and inhibits the expression of toll-like receptor 4. CANCER CELL INT. 2023 Dec;23(1):1-9 FCM ; Human,Mouse.
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| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號 | 3D4 |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 90kDa |
| 檢測分子量 | 110 |
| 性 狀 | Liquid |
| 亞 型 | Mouse IgG2a, κ |
| 純化方法 | Affinity purified by Protein G |
| 緩 沖 液 | 0.01M PBS, 0.5%BSA, 0.03% Proclin300 |
| 保存條件 | Store at 2-8℃. Protect from light. Avoid freezing. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020] SWISS: O00206 Gene ID: 7099 |
