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DAPK1 Mouse mAb (bsm-51758M)  
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產品編號 bsm-51758M
英文名稱 DAPK1 Mouse mAb
中文名稱 死亡相關蛋白激酶1單克隆抗體
別    名 DAP Kinase 1; DAK1; DAP K1; DAPK 1; DAPK; Death Associated Protein Kinase 1; Death Associated Protein Kinase 1; Death-associated protein kinase 1; DKFZp781I035; DAPK1_HUMAN  
研究領域 腫瘤  細胞生物  信號轉導  細胞凋亡  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 F5T7
交叉反應 Human (predicted: Mouse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 160 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DAPK1 
亞    型 IgG2a, κ
純化方法 affinity purified by Protein G
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 DAPK1 expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlates with high rates of metastasis. The loss of DAPK expression provides a link between suppression of apoptosis and metastasis. DAPK1 is thought be involved in an early apoptotic checkpoint which eliminates premalignant cells from cancer formation. Studies in bladder cancer patients have also shown that hypermethylation of DAPK1 correlates to high recurrence rates and thus DAPK1 may be used as a prognostic marker. DAPK1 is also reportedly a molecular regulator of neuronal death in epilepsy.

Function:
Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.

Subunit:
Interacts with KLHL20. Interacts (via death domain) with MAPK1 and MAPK3. Interacts with MAP1B (via N-terminus). Interacts (via death domain) with UNC5B (via death domain). Interacts with PRKD1 in an oxidative stress-regulated manner. Interacts with PIN1, PDCD6, BECN1, GRINB, TSC2 and STX1A. Interacts (via kinase domain) with DAPK3 (via kinase domain).

Subcellular Location:
Cytoplasm. Colocalizes with the actin filament system.

Tissue Specificity:
Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas.

Post-translational modifications:
Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex, leading to its degradation by the proteasome.

Similarity:
Belongs to the protein kinase superfamily.
CAMK Ser/Thr protein kinase family.
DAP kinase subfamily.

SWISS:
P53355

Gene ID:
1612

Database links:

Entrez Gene: 1612 Human

Entrez Gene: 69635 Mouse

SwissProt: P53355 Human

SwissProt: Q80YE7 Mouse



產品圖片
Sample: Lane 1: A549 cell lysates Primary: Anti-DAPK1 (bsm-51758M) at 1/4000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 160 kD Observed band size: 160 kD
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