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Bak Rabbit pAb (bs-22928R)  
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產品編號 bs-22928R
英文名稱 Bak Rabbit pAb
中文名稱 Bcl-2同源拮抗劑抗體
別    名 Apoptosis Regulator Bak; BAK 1; BAK; BAK like; Bak NT; BAK1; Bcl 2 homologous antagonist/killer; Bcl 2 like 7 protein; Bcl2 homologous antagonist killer; Bcl2 like 7 Protein; BCL2-antagonist/killer 1; BCL2L7; CDN 1; CDN1; Cell death inhibitor 1; MGC117255; MGC3887; NBak; Pro apoptotic protein BAK; BAK_HUMAN; BAK_MOUSE  
Specific References  (1)     |     bs-22928R has been referenced in 1 publications.
[IF=7.963] Jianzhao Liao. et al. Gut microbiota disturbance exaggerates battery wastewater-induced hepatotoxicity through a gut-liver axis. Sci Total Environ. 2022 Feb;809:152188  WB ;  Mouse.  
研究領域 免疫學  細胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 23 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Bak: 71-171/211 
亞    型
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

Function:
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.

Subunit:
Belongs to the Bcl-2 family.

Subcellular Location:
Mitochondrion membrane.

Tissue Specificity:
Expressed in a wide variety of tissues.

Similarity:
Belongs to the Bcl-2 family.

SWISS:
Q16611

Gene ID:
578

Database links:
Entrez Gene: 578 Human
Entrez Gene: 12018 Mouse
Omim: 600516 Human
SwissProt: Q16611 Human
SwissProt: Q6I9T6 Human
SwissProt: O08734 Mouse
Unigene: 485139 Human
Unigene: 2443 Mouse


Bak屬于bcl-2基因家族中的成員,具有抑制凋亡的作用。BAK基因是新發(fā)現(xiàn)的細胞凋亡促進因子,BAK含BH1和BH2結構域,其功能類似于BAX;拮抗BCL2、BCL-XL的抗凋亡效應。
產品圖片
Sample: Lane 1: Molt-4 (Human) Cell Lysate at 30 ug Lane 2: Jurkat (Human) Cell Lysate at 30 ug Primary: Anti-Bak (bs-22928R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 23 kD Observed band size: 25 kD
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