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CoREST2 Rabbit pAb (bs-13993R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-13993R
英文名稱(chēng) CoREST2 Rabbit pAb
中文名稱(chēng) CoREST2蛋白抗體
別    名 1A13; co repressor of Rest; co-repressor of Rest; coREST; M-CoREST; Rcor; Rcor1; RCOR2; RCOR2_HUMAN; RE1 silencing transcription factor(REST) co repressor 1; RE1-silencing transcription factor(REST) co-repressor 1; REST co-repressor 2; REST corepressor 2.  
研究領(lǐng)域 神經(jīng)生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Human (predicted: Mouse,Rat,Pig,Sheep,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 58 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CoREST2: 151-250/523 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 ?In mammals, the CoREST complex is a chromatin-modifying structure that, through interactions with NRSF (neuron restrictive silencer factor), regulates neuronal gene expression and neuronal cell fate. RCOR2 (REST corepressor 2) and RCOR3 (REST corepressor 3) are nuclear proteins that each contain one ELM2 domain and two SANT domains. RCOR2 and RCOR3, both members of the CoREST family, are thought to function as components of the CoREST complex; possibly playing a role in the transcriptional repression of neuronal genes. Additionally, RCOR2 and RCOR3, in conjunction with CoREST, can form immunocomplexes with a variety of histone-modifying genes, including G9a and HDAC1. Via these protein complexes, RCOR2 and RCOR3 can further regulate transcription by controlling the methylation and demethylation of target genes during early development. While RCOR2 is expressed as only one known isoform, RCOR3 exists as two isoforms due to alternative splicing events.

Function:
May act as a component of a corepressor complex that represses transcription.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the CoREST family.
Contains 1 ELM2 domain.
Contains 2 SANT domains.

SWISS:
Q8IZ40

Gene ID:
283248

Database links:

Entrez Gene: 283248 Human

Entrez Gene: 104383 Mouse

Entrez Gene: 305811 Rat

Entrez Gene: 498485 Rat

SwissProt: Q8IZ40 Human

SwissProt: Q8C796 Mouse

SwissProt: Q5FWT8 Rat

Unigene: 98788 Human

Unigene: 283859 Mouse

Unigene: 110225 Rat

Unigene: 209048 Rat



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