| 產(chǎn)品編號 | bs-12889R |
| 英文名稱 | BRD3 Rabbit pAb |
| 中文名稱 | BRD3蛋白抗體 |
| 別 名 | BRD 3; Brd3; BRD3_HUMAN; Bromodomain containing 3; Bromodomain containing protein 3; Bromodomain-containing protein 3; KIAA0043; Open reading frame X; ORFX; RING3 like gene; RING3-like protein; RING3L. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 80 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BRD3: 601-700/726 |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The bromodomain-containing proteins include BRD2, BRD3, BRD4 and BRDT. BRD2 (RING3 protein) is a mitogen-activated nuclear protein whose gene is located in the human MHC II region, suggesting its relation to HLA-associated diseases. The gene encoding BRD3 (RING3-like protein) contains two bromodomains and maps to chromosome 9q34. BRD4 (HUNK1 protein) is a nuclear protein involved in the regulation of chromosomal dynamics during mitosis. The testis-specific bromodomain protein BRDT contains a PEST sequence, indicating that it undergoes rapid intracellular degradation. The bromodomain-containing proteins are ubiquitously expressed. Function: Binds hyperacetylated chromatin and plays a role in theregulation of transcription, probably by chromatin remodeling andinteraction with transcription factors. Regulates transcription bypromoting the binding of the transcription factor GATA1 to itstargets (By similarity). Regulates transcription of the CCND1 gene. Subunit: Interacts (via bromo domain 1) with GATA1 acetylated at'Lys-312' and 'Lys-315'. Interacts (via bromo domain 1) with GATA2acetylated on lysine residues (By similarity). Interacts (via bromodomains) with acetylated lysine residues on the N-terminus ofhistone H2A, H2B, H3 and H4 (in vitro). Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous. DISEASE: Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. Similarity: Contains 2 bromo domains. SWISS: Q15059 Gene ID: 8019 Database links: Entrez Gene: 8019 Human Omim: 601541 Human SwissProt: Q15059 Human Unigene: 522472 Human Unigene: 654869 Human |
