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Liprin alpha 1 Rabbit pAb (bs-11463R)  
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50ul/1180.00元
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產品編號 bs-11463R
英文名稱 Liprin alpha 1 Rabbit pAb
中文名稱 酪氨酸磷酸酶受體相互作用蛋白Liprin α1抗體
別    名 PPFIA1; LAR interacting protein 1; LIP 1; LIP.1; LIP1; LIPRIN; MGC26800; PPFIA 1; PPFIA1; Protein tyrosine phosphatase receptor type f polypeptide(PTPRF) interacting protein(liprin) alpha 1; Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 1; PTPRF interacting protein alpha 1; LIPA1_HUMAN.  
Specific References  (2)     |     bs-11463R has been referenced in 2 publications.
[IF=2.314] Che H et al. circ_0080145 Enhances Imatinib Resistance of Chronic Myeloid Leukemia by Regulating miR-326/PPFIA1 Axis. Cancer Biother Radiopharm. 2020 Jun 27.  WB ;  Human.  
[IF=2.314] Hong Cheet al. circ_0080145 Enhances Imatinib Resistance of Chronic Myeloid Leukemia by Regulating miR-326/PPFIA1 Axis. Cancer Biother Radiopharm . 2020 Jun 27.  WB ;  Human.  
研究領域 神經生物學  信號轉導  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 136 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Liprin alpha 1: 141-190/1202 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a member of the LARprotein-tyrosine phosphatase-interacting protein (liprin) family.Liprins interact with members of LAR family of transmembraneprotein tyrosine phosphatases, which are known to be important foraxon guidance and mammary gland development. This protein binds tothe intracellular membrane-distal phosphatase domain of tyrosinephosphatase LAR, and appears to localize LAR to cell focaladhesions. This interaction may regulate the disassembly of focaladhesion and thus help orchestrate cell-matrix interactions.Alternatively spliced transcript variants encoding distinctisoforms have been described. [provided by RefSeq, Jul 2008].

Function:
This protein is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions.

Subunit:
Forms homodimers and heterodimers with liprins-alpha andliprins-beta. Interacts with the second PTPase domain of PTPRD,PTPRF and PTPRS. Interacts with GIT1, KIF1A and GRIP1

Subcellular Location:
Cytoplasm. Note=Colocalizes with PTPRF atthe ends of focal adhesions most proximal to the cell nucleus.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the liprin family. Liprin-alpha subfamily.
Contains 3 SAM (sterile alpha motif) domains.

SWISS:
Q13136

Gene ID:
8500

Database links:

Entrez Gene: 8500 Human

Entrez Gene: 233977 Mouse

Entrez Gene: 293645 Rat

Omim: 611054 Human

SwissProt: Q13136 Human

Unigene: 530749 Human

Unigene: 708791 Human



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