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Pumilio 1 Rabbit pAb (bs-11218R)  
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50ul/1180.00元
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產(chǎn)品編號 bs-11218R
英文名稱 Pumilio 1 Rabbit pAb
中文名稱 PUM1蛋白抗體
別    名 HSPUM; KIAA0099; PUM 1; PUM L1; PUM1; PUM1_HUMAN; PUMH 1; PUMH; PUMH1; Pumilio homolog 1; Pumilio-1; Pumilio1; PUML 1; PUML1.  
研究領域 發(fā)育生物學  干細胞  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat,Rabbit,Pig,Sheep,Cow,Dog)
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 126 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Pumilio 1: 201-300/1186 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Pumilio 1, also known as PUM1, PUMH1 (Pumilio homolog 1), HSPUM, PUMH or PUML1, is a homolog of the Drosophila Pumilio protein and belongs to the PUF family. The PUF family is comprised of evolutionarily conserved proteins that contain a C-terminal RNA binding domain made up of eight highly conserved tandem repeats. PUF proteins function as sequence-specific RNA-binding proteins and bind NREs (nanos response elements) in the 3’-untranslated regions of target mRNAs. They play an important role mediating mRNA stabilization and repressing translation. Pumilio 1 is a typical PUF protein expressed in fetal tissues as well as adult stomach, kidney, intestine, muscle, brain and heart tissues. Pumilio 1 localizes to the cytoplasm and is believed to participate in cell fate, cell development, cell differentiation and maintenance of somatic stem cells.

Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).

Subunit:
Binds in a sequence-specific manner to the 3'-UTR of some mRNAs.

Subcellular Location:
Cytoplasm (Probable).

Tissue Specificity:
Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested.

Similarity:
Contains 1 PUM-HD domain.
Contains 8 pumilio repeats.

SWISS:
Q14671

Gene ID:
9698

Database links:

Entrez Gene: 9698 Human

Entrez Gene: 80912 Mouse

Omim: 607204 Human

SwissProt: Q14671 Human

SwissProt: Q80U78 Mouse

Unigene: 281707 Human

Unigene: 440206 Mouse



產(chǎn)品圖片
Sample: Stomach (Mouse) Lysate at 40 ug Primary: Anti- Pumilio 1 (bs-11218R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 126 kD Observed band size: 126 kD
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