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C1orf80 Rabbit pAb (bs-9802R)  
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產(chǎn)品編號 bs-9802R
英文名稱 C1orf80 Rabbit pAb
中文名稱 1號染色體開放閱讀框80抗體
別    名 dorsalization-associated protein; AIDA; AIDA_HUMAN; Axin interaction partner and dorsalization antagonist; Axin interactor; Axin interactor, dorsalization associated; Chromosome 1 open reading frame 80; UPF0491 protein C1orf80.  
研究領(lǐng)域 細胞生物  發(fā)育生物學  信號轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Human (predicted: Mouse,Rat,Pig,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 35 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human C1orf180/AIDA: 221-306/306 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 AIDA, also known as C1orf80, is a 306 amino acid protein that belongs to the axin interactor family. Expressed in a variety of tissues, including skeletal muscle and heart, AIDA functions as a ventralizing factor during embryogenesis, disrupting Axin homodimerization and inhibiting Axin-mediated JNK activation. Axin, a scaffold protein, is important for both JNK signaling and the canonical Wnt pathway, two processes that play an essential role in embryonic dorsoventral patterning. Disruption of Axin by AIDA results in the negative regulation of JNK and Wnt signaling, thereby affecting embryonic developmental events. Three isoforms of AIDA exist due to alternative splicing events.

Function:
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).

Subunit:
Interacts with AXIN1 (By similarity).

Tissue Specificity:
Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle.

Similarity:
Belongs to the AIDA family.

SWISS:
Q96BJ3

Gene ID:
64853

Database links:

Entrez Gene: 64853 Human

Omim: 612375 Human

SwissProt: Q96BJ3 Human

Unigene: 156625 Human

Unigene: 534965 Human



產(chǎn)品圖片
Sample: K562 Cell (Human) Lysate at 40 ug Primary: Anti-C1orf80 (bs-9802R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kD Observed band size: 34 kD
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