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JMJD5 Rabbit pAb (bs-8047R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產(chǎn)品編號 bs-8047R
英文名稱 JMJD5 Rabbit pAb
中文名稱 組蛋白去甲基化酶JMJD5抗體
別    名 JmjC domain-containing protein 5; JMJD5; JMJD5 protein; jumonji domain containing 5; Jumonji domain-containing protein 5; KDM8_HUMAN; Lysine-specific demethylase 8.  
研究領域 細胞生物  染色質(zhì)和核信號  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 47 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human JMJD5: 344-416/416 
亞    型
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009].

Function:
Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.

Subcellular Location:
Nucleus.

Tissue Specificity:
Weakly expressed in most cells. Highly expressed in breast cancer cells.

Similarity:
Contains 1 JmjC domain.

SWISS:
Q8N371

Gene ID:
79831

Database links:

Entrez Gene: 79831 Human

Entrez Gene: 77035 Mouse

Entrez Gene: 308976 Rat

Omim: 611917 Human

SwissProt: Q8N371 Human

SwissProt: Q9CXT6 Mouse

SwissProt: Q497B8 Rat

Unigene: 145717 Human



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (human gastric carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (JMJD5) Polyclonal Antibody, Unconjugated (bs-8047R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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