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NRH2 Rabbit pAb (bs-7672R)  
訂購熱線:400-901-9800
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-7672R
英文名稱 NRH2 Rabbit pAb
中文名稱 死亡結構域蛋白NRH2抗體
別    名 NRADD; PLAIDD; NRADD_RAT; Death domain-containing membrane protein NRADD; Neurotrophin receptor homolog-2; Neurotrophin receptor-alike death domain protein; P75-like apoptosis-inducing death domain protein.  神經營養(yǎng)因子受體相似的死亡結構域蛋白;
研究領域 細胞生物  細胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Mouse,Rat,Pig,Sheep,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 24 kDa
檢測分子量
細胞定位 細胞核 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat NRH2: 51-150/228 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 A single transmembrane protein highly expressed in embryonic tissues and involved in inducing apoptosis.

Function:
Modulates NTRK1 signaling. Can activate severalintracellular signaling pathways, leading to activation of JUN.Promotes translocation of SORT1 to the cell membrane, and therebyhinders lysosomal degradation of SOTR1 and promotes its interactionwith NGFR (By similarity). Both isoform 1 and isoform 2 promoteapoptosis.

Subunit:
Interacts with NTRK1. Isoform 1 andisoform 2 interact with NGFR. Interacts with SORT1.

Subcellular Location:
Cell membrane; Single-pass type III membraneprotein. Nucleus (By similarity). Note=Proteolytic processing givesrise to an intracellular domain that translocates to the nucleus.

Tissue Specificity:
Detected in embryo, including embryonic brain.Detected at very low levels in adult testis, spleen, thymus andlung.

Post-translational modifications:
Isoform 1 is N-glycosylated. Isoform 2 is not N-glycosylated.

Similarity:
Contains 1 death domain.

Database links:

 



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