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Scavenger Receptor BII Rabbit pAb (bs-7545R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產品編號 bs-7545R
英文名稱 Scavenger Receptor BII Rabbit pAb
中文名稱 清道夫受體B2抗體
別    名 85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B member 2; AMRF; CD36; CD36 antigen(collagen type I receptor, thrombospondin receptor)-like 2(lysosomal integral membrane protein II); CD36 antigen; CD36 antigen-like 2; CD36L2; EPM4; HLGP85; LGP85; LIMP 2; LIMP II; LIMP2; LIMPII; Lysosomal integral membrane protein II; Lysosome membrane protein 2; Lysosome membrane protein II; OTTHUMP00000160590; OTTHUMP00000219176; Scarb2; Scavenger receptor class B member 2; Scavenger receptor class B, member 2; SCRB2_HUMAN; SR BII; SRBII.  
研究領域 腫瘤  心血管  細胞生物  信號轉導  轉錄調節(jié)因子  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 52 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Scavenger Receptor BII: 181-280/478 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

Function:
Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.

Subunit:
Interacts with GBA (via the coiled-coil domain).

Subcellular Location:
Lysosome membrane; Multi-pass membrane protein.

DISEASE:
Defects in SCARB2 are the cause of progressive myoclonic epilepsy type 4 with or without renal failure (EPM4) [MIM:254900]. An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. Cognitive function is preserved.
Note=Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease.

Similarity:
Belongs to the CD36 family.

SWISS:
Q14108

Gene ID:
950

Database links:

Entrez Gene: 950 Human

Entrez Gene: 12492 Mouse

Entrez Gene: 117106 Rat

Omim: 602257 Human

SwissProt: Q14108 Human

SwissProt: O35114 Mouse

SwissProt: P27615 Rat

Unigene: 349656 Human

Unigene: 297964 Mouse

Unigene: 3957 Rat



產品圖片
Sample: Hela Cell (Human) Lysate at 40 ug Primary: Anti-Scavenger Receptor BII (bs-7545R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 52 kD
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