| 產(chǎn)品編號 | bs-5803R |
| 英文名稱 | API2/BIRC3 Rabbit pAb |
| 中文名稱 | 凋亡抑制因子2抗體 |
| 別 名 | cIAP2; CIAP 2; CIAP-2; Inhibitor of apoptosis protein 1; AIP 1; AIP1; API 2; API2; Apoptosis inhibitor 2; Baculoviral IAP repeat containing 3; Baculoviral IAP repeat containing protein 3; Baculoviral IAP repeat-containing protein 3; BIRC 3; BIRC3; BIRC3_HUMAN; C IAP2; C-IAP2; CIAP 2; CIAP2; HAIP 1; HAIP1; HIAP 1; HIAP-1; HIAP1; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; MALT 2; MALT2; Mammalian IAP homolog C; MIHC; RING finger protein 49; RNF49; TNFR2 TRAF signaling complex protein 1; TNFR2 TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 1. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 細(xì)胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Pig,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 68 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human cIAP2: 511-604/604 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Function: Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Subunit: Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interacts with RIP1, RIP2, RIP3, RIP4 and USP19. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes. DISEASE: Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. Similarity: Belongs to the IAP family. Contains 3 BIR repeats. Contains 1 CARD domain. Contains 1 RING-type zinc finger. SWISS: Q13489 Gene ID: 330 Database links: Entrez Gene: 330 Human Entrez Gene: 11796 Mouse Omim: 601721 Human SwissProt: Q13489 Human SwissProt: O08863 Mouse Unigene: 127799 Human Unigene: 2026 Mouse Unigene: 64578 Rat |
| 產(chǎn)品圖片 |
Sample:
Lung (Mouse) Lysate at 40 ug
Primary: Anti- API2/BIRC3 (bs-5803R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 68 kD
Observed band size: 65 kD
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