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PTPN7 Rabbit pAb (bs-4155R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-4155R
英文名稱 PTPN7 Rabbit pAb
中文名稱 非受體型蛋白酪氨酸磷酸酶7抗體
別    名 HePTP; BPTP 4; BPTP4; Dual specificity phosphatase 1; Hematopoietic protein tyrosine phosphatase; LC PTP; LCPTP; LPTP; Protein tyrosine phoshatase non receptor type stress induced; Protein tyrosine phoshatase nonreceptor type stress induced; Protein tyrosine phosphatase LC PTP; Protein tyrosine phosphatase non receptor type 7; PTPN 7; PTPNI; Tyrosine protein phosphatase non receptor type 7; PTN7_HUMAN.  
研究領域 腫瘤  免疫學  信號轉導  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Cow,Dog)
產(chǎn)品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 40 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTPN7: 261-360/465 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].

Function:
Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.

Subunit:
Monomer. Interacts with MAPK1, MAPK3 and several other MAP kinases.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed exclusively in thymus and spleen.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Contains 1 tyrosine-protein phosphatase domain.

SWISS:
P35236

Gene ID:
5778

Database links:

Entrez Gene: 5778 Human

Entrez Gene: 320139 Mouse

Entrez Gene: 246781 Rat

Omim: 176889 Human

SwissProt: P35236 Human

SwissProt: Q8BUM3 Mouse

SwissProt: P49445 Rat

Unigene: 402773 Human

Unigene: 258388 Mouse

Unigene: 10160 Rat



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