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SRP68 Rabbit pAb (bs-2381R)  
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50ul/1180.00元
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產(chǎn)品編號 bs-2381R
英文名稱 SRP68 Rabbit pAb
中文名稱 信號識別顆??贵w
別    名 Signal recognition particle 68 kDa; Signal recognition particle subunit SRP68; Signal recognition particle 68 kDa protein; SRP 68; Srp68; SRP68_HUMAN.  
研究領域 免疫學  染色質(zhì)和核信號  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Rat (predicted: Mouse,Rabbit,Cow,Chicken,Dog,Horse)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 71 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SRP68: 401-500/627 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

Function:
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

Subunit:
Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

Subcellular Location:
Cytoplasm. Nucleus, nucleolus.

Similarity:
Belongs to the SRP68 family.

SWISS:
Q9UHB9

Gene ID:
6730

Database links:

Entrez Gene: 6730 Human

Entrez Gene: 217337 Mouse

Entrez Gene: 363707 Rat

Omim: 604858 Human

SwissProt: Q9UHB9 Human

SwissProt: Q8BMA6 Mouse

Unigene: 514495 Human

Unigene: 29655 Mouse

Unigene: 68 Rat



信號識別顆粒(Signalrecognitionparticle,SRP)是介導蛋白識別轉(zhuǎn)運其中普遍存在的機制之一,細胞內(nèi)蛋白質(zhì)的定向轉(zhuǎn)移是蛋白質(zhì)質(zhì)量數(shù)量控制體系的一個重要環(huán)節(jié),SRP對參與這一過程的功能基因和蛋白,尤其是蛋白的靶向輸送機制的研究對揭示細胞的分化、代謝和病變具有重大的理論意義.
產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SRP68) Polyclonal Antibody, Unconjugated (bs-2381R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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