| 產(chǎn)品編號 | bs-2413R |
| 英文名稱 | PAX7 Rabbit pAb |
| 中文名稱 | 配對盒基因7抗體 |
| 別 名 | Paired box gene 7; FLJ37460; HUP1; OTTHUMP00000002534; Paired box 7; Paired box homeotic gene 7; Paired box protein Pax-7; Paired domain gene 7; Paired domain gene HuP1; PAX7 transcriptional factor; PAX7/FKHR fusion gene, included; PAX7B; RGD1564360; PAX7_HUMAN. |
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Specific References (8) | bs-2413R has been referenced in 8 publications.
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| 研究領(lǐng)域 | 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Rabbit,Pig,Sheep,Cow,Chicken,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 55 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PAX7: 401-500/520 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
PAX7 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of PAX7 is unknown but it is speculated to be involved in tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Alternative splicing in this gene has produced two known products but the biological significance of the variants is unknown.
Function: Probable transcription factor. May have a role in myogenesis. Subunit: Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX. Subcellular Location: Nucleus. DISEASE: Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2) [MIM:268220]. It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator. Similarity: Belongs to the paired homeobox family. Contains 1 homeobox DNA-binding domain. Contains 1 paired domain. SWISS: P23759 Gene ID: 5081 Database links: Entrez Gene: 5081 Human Entrez Gene: 18509 Mouse Omim: 167410 Human SwissProt: P23759 Human SwissProt: P47239 Mouse Unigene: 113253 Human Unigene: 218760 Mouse Unigene: 226327 Rat 同源結(jié)構(gòu)域蛋白（Homeodomain Proteins） PAX-7屬于轉(zhuǎn)錄抑制因子。在胚胎發(fā)育和腫瘤生長中起關(guān)鍵作用。其突變和某些腫瘤的發(fā)病有關(guān)。 |
| 產(chǎn)品圖片 |
Sample:
Uterus(Mouse) Lysate at 40 ug
Skeletal muscle(Rat) Lysate at 40 ug
Skeletal muscle(Mouse) Lysate at 40 ug
Primary: Anti-PAX7 (bs-2413R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 56 kD
Observed band size: 56 kD
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