| 產(chǎn)品編號 | bs-2453R |
| 英文名稱 | CCL17 Rabbit pAb |
| 中文名稱 | 胸腺活化調(diào)節(jié)趨化因子抗體 |
| 別 名 | TARC; CCL17; SCYA17; ABCD-2; C-C motif chemokine 17; A152E53; CC Chemokine TARC; CCL17; Chemokine CC Motif Ligand 17; MGC138271; MGC138273; Small Inducible Cytokine A17; Small Inducible Cytokine A17 Precursor; Small Inducible Cytokine Subfamily A(Cys Cys); Small Inducible Cytokine Subfamily A(Cys Cys) Member 17; T Cell Directed CC Chemokine; Thymus and activation regulated chemokine; CCL17_HUMAN. |
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Specific References (4) | bs-2453R has been referenced in 4 publications.
[IF=5.34] Dian-Dong Hou. et al. Therapeutic effects of myricetin on atopic dermatitis in vivo and in vitro. PHYTOMEDICINE. 2022 Jul;102:154200 IHC ; Mouse.
[IF=4.51] Chen, Yi-Lien, and Bor-Luen Chiang. "Targeting TSLP With shRNA Alleviates Airway Inflammation and Decreases Epithelial CCL17 in a Murine Model of Asthma." Molecular Therapy—Nucleic Acids 5.5 (2016): e316. IHC-P ; Mouse.
[IF=3.361] Hou DD et al. Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis. Int Immunopharmacol. 2019 Jun 7;74:105676. IHC-P ; Mouse.
[IF=2.264] Zhiyu Zhang. et al. CCL17 blockade by CCL17mAb/GSK-J4 ameliorates hyperalgesia in a rat model of postoperative pain. BIOL PHARM BULL. 2023 Feb 15 IF ; Rat.
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| 研究領(lǐng)域 | 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 8 kDa |
| 檢測分子量 | |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CCL17: 41-103/103 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. TARC displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. TARC binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. Function: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. Subcellular Location: Secreted. Tissue Specificity: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine. Post-translational modifications: One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain. Similarity: Belongs to the intercrine beta (chemokine CC) family. SWISS: Q92583 Gene ID: 6361 Database links: Entrez Gene: 6361 Human Entrez Gene: 20295 Mouse Omim: 601520 Human SwissProt: Q92583 Human Unigene: 546294 Human Unigene: 41988 Mouse Unigene: 46679 Rat |
