| 產(chǎn)品編號(hào) | bsm-62128R |
| 英文名稱 | DISC1 Recombinant Rabbit mAb |
| 中文名稱 | DISC1重組兔單抗 |
| 別 名 | C1orf136; DISC1; KIAA0457; RP4-730B13.1; SCZD9. |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,IHC-P=1:100-1:200,IHC-F=1:100-1:200,IF=1:50-1:200,Flow-Cyt=1:20-1:100,ICC/IF=1:50-1:200,IP=1:20-1:50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 94 kDa |
| 檢測(cè)分子量 | 100 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human DISC1: 1-120/854 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis.Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus.Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. SWISS: Q9NRI5 Gene ID: 27185 DISC-1基因的變異增加了患精神分裂癥的風(fēng)險(xiǎn)。研究人員發(fā)現(xiàn)，抑制老鼠的DISC1活性則改變了動(dòng)物大腦的發(fā)育，引起了大腦皮層輕微的變異，而在對(duì)精神分裂癥病人進(jìn)行尸檢時(shí)在其大腦中見(jiàn)到了此變化。研究人員還發(fā)現(xiàn)將DISC1與對(duì)大腦發(fā)育和調(diào)節(jié)神經(jīng)傳遞素水平很重要的分子信號(hào)路徑聯(lián)系起來(lái)，精神病患者的神經(jīng)傳遞素水平往往是不正常的。 新研究顯示DISC1蛋白質(zhì)與一個(gè)叫PDE4B的酶相互作用，而影響信號(hào)傳遞分子cAMP的活性。這個(gè)信號(hào)傳遞系統(tǒng)過(guò)去在其它試驗(yàn)系統(tǒng)中被發(fā)現(xiàn)與學(xué)習(xí)、記憶、以及情緒有關(guān)， |
| 產(chǎn)品圖片 |
Western blot analysis of (1) HeLa cell lysate; (2) RAW264.7 cell lysate; (3) PC-12 cell lysate. Using DISC1 (bsm-62128R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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