| 產(chǎn)品編號(hào) | bsm-61436R |
| 英文名稱 | TIMP-2 Recombinant Rabbit mAb |
| 中文名稱 | 金屬蛋白酶組織抑制因子-2重組兔單抗 |
| 別 名 | CSC21K; TIMP 2; TIMP2. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 24 kDa |
| 檢測(cè)分子量 | 22 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human TIMP2: 170-220/220 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. SWISS: P16035 Gene ID: 7077 合成與降解（Synthesis and Degradation） TIMP-2與TIMP-1一樣是基質(zhì)金屬蛋白酶的抑制酶，其功能與MMP相反，能抑制腫瘤細(xì)胞的浸潤(rùn)和轉(zhuǎn)移，主要用于各種惡性腫瘤如乳腺癌等的研究。TIMP-2又稱為CSC-21K，是一種21-24kDa的糖蛋白，在多種組織細(xì)胞中表達(dá)，它可以和MMPs家族成員以共價(jià)鍵方式形成復(fù)合物，從而發(fā)揮其抑制作用。在正常生理?xiàng)l件下，MMPs和TIMPs之間的平衡狀態(tài)是維持細(xì)胞外基質(zhì)正常狀態(tài)所必需的，一旦它們之間的比例失調(diào)，就會(huì)造成一系列的病理狀態(tài)。 |
| 產(chǎn)品圖片 |
Western blot analysis of HeLa cell lysate. Using TIMP-2 (bsm-61436R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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