| 產(chǎn)品編號(hào) | bsm-61426R |
| 英文名稱 | Aromatase Recombinant Rabbit mAb |
| 中文名稱 | 芳香化酶/細(xì)胞色素P450/雌激素合成酶重組兔單抗 |
| 別 名 | Aromatase; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase; CYP19A1; ARO1; CYAR; CYP19. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | 2F4 |
| 交叉反應(yīng) | Human,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-1:2000,IP=1:20-1:50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 58 kDa |
| 檢測(cè)分子量 | 53 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Aromatase: 1-69 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. SWISS: P11511 Gene ID: 1588 芳香化酶是一種微粒體酶系統(tǒng)，催化睪酮經(jīng)三步連續(xù)強(qiáng)化轉(zhuǎn)變成17-β-雌二醇,在反應(yīng)中睪酮作為激素原。 細(xì)胞色素P450主要分布在內(nèi)質(zhì)網(wǎng)和線粒體內(nèi)膜上，作為一種末端加氧酶，參與了生物體內(nèi)的甾醇類激素合成等過程。 近年來，對(duì)細(xì)胞色素P450的結(jié)構(gòu)、功能特別是對(duì)其在藥物代謝中的作用的研究有了較大的進(jìn)展。 最新研究表明細(xì)胞色素P450還是藥物代謝過程中的關(guān)鍵酶，而且對(duì)細(xì)胞因子和體溫調(diào)節(jié)都有重要影響。 芳香化酶-細(xì)胞色素P450作為和藥物代謝及細(xì)胞因子相關(guān)的重要酶類，在藥物代謝和免疫中起著相當(dāng)重要的作用，對(duì)于它的研究 |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with Aromatase monoclonal antibody, unconjugated (bsm-61426R) at 1:2000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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